@article {125,
	title = {Postprandial response improvement via safety layer in closed-loop blood glucose controllers},
	journal = {Biomedical Signal Processing and Control},
	volume = {16},
	year = {2015},
	pages = {80-87},
	abstract = {<p>Traditional type 1 diabetes therapies are prone to show poor glucose regulation especially in the postprandial period owing to both physiological and technological limitations. Although a closed-loop controller for glucose regulation has to be tuned to minimize the postprandial excursion and avoid late hypoglycemia, the intrinsic limitations of the problem lead to a trade-off between postprandial peak and late hypoglycemia risk. This paper reveals through an intensive in-silico study with multiple controller tuning combinations that a novel safety layer for glucose controllers, the so-called SAFE loop (Revert et al., 2013), not only reduces the hypoglycemia events but also allows reducing the postprandial glucose excursion, thus breaking the implicit trade-off present in single controllers. The SAFE outer loop monitors the estimated amount of insulin on board, and modifies the control action if it is close to a unique constraint which can be adjusted with clinical criteria. A very challenging test scenario is here implemented including the rate of blood glucose appearance from intakes of mixed meals, diurnal and day-to-day time-varying metabolic changes, inherent drawbacks in sensor and actuator, and other realistic conditions. The results show a significant reduction of hypoglycemia events when SAFE is added, regardless the closed-loop glucose controller, together with a potential postprandial response improvement.</p>
},
	doi = {10.1016/j.bspc.2014.10.003},
	url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84910030806\&partnerID=40\&md5=23aa19a2b59e400d05ae30435b8b33e2},
	author = {Le{\'o}n-Vargas, Fabi{\'a}n and Garelli, Fabricio and De Battista, Hern{\'a}n and Veh{\'\i}, Josep}
}
