Automatic glycemic regulation for the pediatric population based on switched control and time-varying IOB constraints: an in silico study

TítuloAutomatic glycemic regulation for the pediatric population based on switched control and time-varying IOB constraints: an in silico study
Tipo de PublicaciónJournal Article
Año de Publicación2020
AutoresFushimi E, Serafini MCecilia, De Battista H, Garelli F
JournalMedical & Biological Engineering & Computing
Fecha de publicaciónJul
ISSN1741-0444
Resumen

Artificial pancreas (AP) systems have shown to improve glucose regulation in type 1 diabetes (T1D) patients. However, full closed-loop performance remains a challenge particularly in children and adolescents, since these age groups often present the worst glycemic control. In this work, an algorithm based on switched control and time-varying IOB constraints is presented. The proposed control strategy is evaluated in silico using the FDA-approved UVA/ Padova simulator and its performance contrasted with the previously introduced Automatic Regulation of Glucose (ARG) algorithm in the pediatric population. The effect of unannounced meals is also explored. Results indicate that the proposed strategy achieves lower hypo- and hyperglycemia than the ARG for both announced and unannounced meals.

URLhttps://doi.org/10.1007/s11517-020-02213-w
DOI10.1007/s11517-020-02213-w
Líneas de investigación: 
Control de sistemas y procesos biológicos
Control of biological processes and systems
Artificial pancreas
Páncreas artificial