Closed-loop growth-rate regulation in fed-batch dual-substrate processes with additive kinetics based on biomass concentration measurement

TitleClosed-loop growth-rate regulation in fed-batch dual-substrate processes with additive kinetics based on biomass concentration measurement
Publication TypeJournal Article
Year of Publication2016
AuthorsNuñez S, Garelli F, De Battista H
JournalJournal of Process Control
Volume44
Pagination14 - 22
ISSN0959-1524
Abstract

This paper deals with the design of feeding rates for dual-substrate fed-batch processes where the main control objective is the regulation of the microbial growth rate. To this end, feedback of the growth rate error is incorporated to a biomass proportional dual feeding law. A second-order sliding mode observer is used to estimate the growth rate, so that no additional sensors are required. Stability conditions are derived and robustness against several disturbances such as yield uncertainty, measurement errors and kinetic model mismatch is analytically and numerically evaluated. The advantages of the proposal include: minimal measurement requirements, regulation with fast convergence to the desired growth rate and reduced regulation error in the presence of disturbances.

DOI10.1016/j.jprocont.2016.05.003
Research Line: 
Control de sistemas y procesos biológicos
Control of biological processes and systems
Control and monitoring of bioprocesses
Control y monitoreo de bioprocesos