Artificial pancreas

Automatic and semi-automatic regulation of glycemia in type 1 diabetes mellitus patients is a long standing control challenge. The main drawback of both open- and closed-loop therapies is the excess of insulin delivered after the meals, which in many cases produces severe hypoglycemia events. Intra-patient variability, delays and lack of accurate on-line blood glucose level measurement impose severe limitations to the achievable performance. We develop control algorithms to reduce the events of hypoglycemia without increasing the risk of hyperglycemia.

 


Publications

Theses

Rosales N.  2020.  Modelado y simulación de tecnologías para el tratamiento de la diabetes.

Patents

De Battista H, Garelli F, León F, Vehí J.  Submitted.  Method and software for the determination and time profile of an insulin dosis.

Book Chapters

Colmegna P, Garelli F, De Battista H, Bianchi FD, Sánchez-Peña R.  2019.  The ARG algorithm: clinical trials in Argentina. The Artificial Pancreas: current situation and future directions. :79-104.

Journal Articles

Fushimi E, Bianchi FDaniel, De Battista H, Garelli F.  2025.  Robust dual-hormone controller for full closed-loop glucose regulation in people with type 1 diabetes: An in silico study. Biocybernetics and Biomedical Engineering. 45:329-339.
Ozaslan B, Aiello EM, Fushimi E, Doyle FJ, Dassau E.  2025.  Personalized Model Identification for Glucose Dynamics From Clinical Data With Incomplete Inputs. IEEE Transactions on Biomedical Engineering. 72:2001-2012.
Saavedra MD, Inthamoussou FA, Fushimi E, Garelli F.  2025.  Identification of Physical Activity Type in People with Diabetes: A Spectrogram-Based Approach. Diabetes Technology and Obesity Medicine. 1:361-373.
Jurao LDa Rosa, Fushimi E, Garelli F.  2025.  Switched Controllers in Fully Closed Loop Insulin Delivery Systems: Reducing the Trade-Off Between Prandial Control and Safety. Artificial Organs. n/a
Fushimi E, Aiello EM, Cho S, Riddell MC, Gal RL, Martin CK, Patton SR, Rickels MR, Doyle FJ.  2024.  Online Classification of Unstructured Free-Living Exercise Sessions in People with Type 1 Diabetes. Diabetes Technology & Therapeutics. 26:709-719.
Bianchi FD, Sánchez-Peña RS, Garelli F.  2023.  Online adjustable linear parameter-varying controller for artificial pancreas systems. Biomedical Signal Processing and Control. 86:105164.
Fushimi E, De Battista H, Garelli F.  2022.  A Dual-Hormone Multicontroller for Artificial Pancreas Systems. IEEE Journal of Biomedical and Health Informatics. :1-8.
Rosales N, De Battista H, Garelli F.  2022.  Hypoglycemia prevention: PID-type controller adaptation for glucose rate limiting in Artificial Pancreas System. Biomedical Signal Processing and Control. 71:103106.
Garelli F, Fushimi E, Rosales N, Arambarri D, Mendoza L, Serafini MCecilia, Moscoso-Vásquez M, Stasi M, Duette P, García-Arabehety J et al..  2022.  First Outpatient Clinical Trial of a Full Closed-Loop Artificial Pancreas System in South America. Journal of Diabetes Science and Technology. :19322968221096162.
Garelli F, Fushimi E, Rosales N, Arambarri D, Serafini MCecilia, De Battista H, Grosembacher L, Sánchez-Peña RSalvador.  2022.  Control no-híbrido de glucemia ensayado en pacientes ambulatorios con Diabetes Tipo 1. Revista Iberoamericana de Automática e Informática industrial.
Rodríguez-Sarmiento DL, León-Vargas F, Garelli F.  2022.  Practical constraint definition in safety schemes for artificial pancreas systems. The International Journal of Artificial Organs. 45:535-542.
Garelli F, Rosales N, Fushimi E, Arambarri D, Mendoza L, De Battista H, Sánchez-Peña R, Arabehety JGarcía, Distefano S, Barcala C et al..  2020.  Remote Glucose Monitoring Platform for Multiple Simultaneous Patients at Coronavirus Disease 2019 Intensive Care Units: Case Report Including Adults and Children. Diabetes Technology & Therapeutics.
Fushimi E, Serafini MCecilia, De Battista H, Garelli F.  2020.  Automatic glycemic regulation for the pediatric population based on switched control and time-varying IOB constraints: an in silico study. Medical & Biological Engineering & Computing.
Moscoso-Vásquez M, Colmegna P, Rosales N, Garelli F, Sánchez-Peña R.  2020.  Control-Oriented Model with Intra-Patient Variations for an Artificial Pancreas. IEEE Journal of Biomedical and Health Informatics. :1-1.
Fushimi E, Colmegna P, De Battista H, Garelli F, Sánchez-Peña R.  2019.  Artificial Pancreas: Evaluating the ARG Algorithm Without Meal Announcement. Journal of Diabetes Science and Technology. :1932296819864585.
García-Jaramillo M, León-Vargas F, Rosales N, Molano A, Garelli F.  2019.  Interval Simulator of the Glucose-Insulin System. Applied Computer Sciences in Engineering.
Colmegna P, Garelli F, De Battista H, Sánchez-Peña R.  2018.  Automatic regulatory control in type 1 diabetes without carbohydrate counting. Control Engineering Practice. 74:22-32.
Rosales N, De Battista H, Vehí J, Garelli F.  2018.  Open-loop glucose control: Automatic IOB-based Super-Bolus feature for commercial insulin pumps. Computer Methods and Programs in Biomedicine. 159:145-158.
Fushimi E, Rosales N, De Battista H, Garelli F.  2018.  Artificial pancreas clinical trials: Moving towards closed-loop control using insulin-on-board constraints. Biomedical Signal Processing and Control. 45:1-9.
Sánchez-Peña R, Colmegna P, Garelli F, De Battista H, García-Violini D, Moscoso-Vásquez M, Rosales N, Fushimi E, Campos-Náñez E, Breton M et al..  2018.  Artificial Pancreas: Clinical Study in Latin America Without Premeal Insulin Boluses. Journal of Diabetes Science and Technology. 12(5):914-925.
Sánchez-Peña R, Colmegna P, Grosembacher L., Breton M., De Battista H, Garelli F, Belloso W.H, Campos-Nánez E., Simonovich V., Beruto V. et al..  2017.  Artificial Pancreas: First Clinical Trials in Argentina. IFAC-PapersOnLine. 50:7731-7736.
León-Vargas F, Garelli F, De Battista H, Vehí J.  2015.  Postprandial response improvement via safety layer in closed-loop blood glucose controllers. Biomedical Signal Processing and Control. 16:80-87.
Revert A, Garelli F, Picó J, De Battista H, Rossetti P, Vehí J, Bondia J.  2015.  Safety auxiliary feedback element for the artificial pancreas in type 1 diabetes. Diabetes Technology and Therapeutics. 17:S35-S36.
Revert A, Garelli F, Picó J, De Battista H, Rossetti P, Vehí J, Bondia J.  2013.  Safety Auxiliary Feedback Element for the Artificial Pancreas in Type 1 Diabetes. Biomedical Engineering, IEEE Transactions on. 60:2113-2122.
León-Vargas F, Garelli F, De Battista H, Vehí J.  2013.  Postprandial blood glucose control using a hybrid adaptive PD controller with insulin-on-board limitation. Biomedical Signal Processing and Control. 8:724-732.